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Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation
An ER transmembrane protein, vesicle-associated membrane protein-associated protein B (VAPB), binds to several organelle-resident membrane proteins to mediate ER-organelle tethering. Mutation in amyotrophic lateral sclerosis (ALS) induces protein misfolding and aggregation, leading to ER disorganiza...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203144/ https://www.ncbi.nlm.nih.gov/pubmed/32376919 http://dx.doi.org/10.1038/s41598-020-64517-z |