Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression

Proteolytic cleavage of influenza A virus (IAV) hemagglutinin by host proteases is crucial for virus infectivity and spread. The transmembrane serine protease TMPRSS2 was previously identified as the essential protease that can cleave hemagglutinin of many subtypes of influenza virus and spike prote...

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Detalles Bibliográficos
Autores principales: Shen, Li-Wen, Qian, Man-Qing, Yu, Kai, Narva, Suresh, Yu, Fei, Wu, Yan-Ling, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203196/
https://www.ncbi.nlm.nih.gov/pubmed/32376987
http://dx.doi.org/10.1038/s41598-020-64368-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203196/
https://www.ncbi.nlm.nih.gov/pubmed/32376987
http://dx.doi.org/10.1038/s41598-020-64368-8

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