Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells

There are eight human Src-family tyrosine kinases (SFKs). SFK members c-Src, c-Yes, Fyn, and Lyn are expressed in various cancer cells. SFK kinase activity is negatively regulated by Csk tyrosine kinase. Reduced activity of Csk causes aberrant activation of SFKs, which can be degraded by a compensat...

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Detalles Bibliográficos
Autores principales: Kuga, Takahisa, Yamane, Yuka, Hayashi, Soujirou, Taniguchi, Masanari, Yamaguchi, Naoto, Yamagishi, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203244/
https://www.ncbi.nlm.nih.gov/pubmed/32376886
http://dx.doi.org/10.1038/s41598-020-64624-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203244/
https://www.ncbi.nlm.nih.gov/pubmed/32376886
http://dx.doi.org/10.1038/s41598-020-64624-x

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