Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility

The transmembrane protein OTK plays an essential role in plexin and Wnt signaling during Drosophila development. We have determined a crystal structure of the last three domains of the OTK ectodomain and found that OTK shows high conformational flexibility resulting from mobility at the interdomain...

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Detalles Bibliográficos
Autores principales: Rozbesky, Daniel, Monistrol, Jim, Jain, Vitul, Hillier, James, Padilla-Parra, Sergi, Jones, E. Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203548/
https://www.ncbi.nlm.nih.gov/pubmed/32187531
http://dx.doi.org/10.1016/j.str.2020.02.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203548/
https://www.ncbi.nlm.nih.gov/pubmed/32187531
http://dx.doi.org/10.1016/j.str.2020.02.008

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