Teriflunomide Does Not Change Dynamics of Nadph Oxidase Activation and Neuronal Dysfunction During Neuroinflammation

The multiple sclerosis therapeutic teriflunomide is known to block the de novo synthesis of pyrimidine in mitochondria by inhibiting the enzyme dihydroorotate-dehydrogenase (DHODH). The metabolic processes of oxidative phosphorylation and glycolysis are further possible downstream targets. In health...

Descripción completa

Detalles Bibliográficos
Autores principales: Mothes, Ronja, Ulbricht, Carolin, Leben, Ruth, Günther, Robert, Hauser, Anja E., Radbruch, Helena, Niesner, Raluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203781/
https://www.ncbi.nlm.nih.gov/pubmed/32426367
http://dx.doi.org/10.3389/fmolb.2020.00062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203781/
https://www.ncbi.nlm.nih.gov/pubmed/32426367
http://dx.doi.org/10.3389/fmolb.2020.00062

Ejemplares similares