IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model

BACKGROUND: Inhibition of inositol-requiring enzyme-1 alpha (IRE1α), one of the sensor signaling proteins associated with endoplasmic reticulum (ER) stress, has been shown to alleviate brain injury and improve neurological behavior in a neonatal hypoxic-ischemic encephalopathy (HIE) rat model. Howev...

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Detalles Bibliográficos
Autores principales: Huang, Juan, Lu, Weitian, Doycheva, Desislava Met, Gamdzyk, Marcin, Hu, Xiao, Liu, Rui, Zhang, John H., Tang, Jiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203836/
https://www.ncbi.nlm.nih.gov/pubmed/32375838
http://dx.doi.org/10.1186/s12974-020-01796-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203836/
https://www.ncbi.nlm.nih.gov/pubmed/32375838
http://dx.doi.org/10.1186/s12974-020-01796-3

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