Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension

Transient receptor potential vanilloid 4 (TRPV4) is a multi-functional non-selective channel expressed in pulmonary vasculatures. TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT response in pulmonary arteries (PAs) of chroni...

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Detalles Bibliográficos
Autores principales: Xia, Yang, Xia, Lexin, Jin, Zhou, Jin, Rui, Paudel, Omkar, Sham, James S. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204149/
https://www.ncbi.nlm.nih.gov/pubmed/32399392
http://dx.doi.org/10.1155/2020/8927381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204149/
https://www.ncbi.nlm.nih.gov/pubmed/32399392
http://dx.doi.org/10.1155/2020/8927381

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