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Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension

Transient receptor potential vanilloid 4 (TRPV4) is a multi-functional non-selective channel expressed in pulmonary vasculatures. TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT response in pulmonary arteries (PAs) of chroni...

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Detalles Bibliográficos
Autores principales:	Xia, Yang, Xia, Lexin, Jin, Zhou, Jin, Rui, Paudel, Omkar, Sham, James S. K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204149/ https://www.ncbi.nlm.nih.gov/pubmed/32399392 http://dx.doi.org/10.1155/2020/8927381

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