Inhibition of Matrix Metalloproteinase with BB-94 Protects against Caerulein-Induced Pancreatitis via Modulating Neutrophil and Macrophage Activation

METHODS: AP was induced in Balb/C mice by ten hourly intraperitoneal injections of caerulein (100 μg/kg) and LPS (5 mg/kg). The MMP inhibitor, BB-94 (20 mg/kg) was intraperitoneally administered 30 min before AP induction. Pancreatitis was confirmed by histology and serum amylase and lipase. Express...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Zengkai, Mulatibieke, Tunike, Niu, Mengya, Li, Bin, Dai, Juanjuan, Ye, Xin, He, Yan, Chen, Congying, Wen, Li, Hu, Guoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204304/
https://www.ncbi.nlm.nih.gov/pubmed/32411205
http://dx.doi.org/10.1155/2020/8903610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204304/
https://www.ncbi.nlm.nih.gov/pubmed/32411205
http://dx.doi.org/10.1155/2020/8903610

Ejemplares similares