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Targeting the Small GTPase Superfamily through Their Regulatory Proteins

The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches essential for numerous cellular processes. Mutations or dysregulation of these proteins are associated with many diseases, but unsuccessful attempts to target the small GTPases directly have resulted in them being classed...

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Detalles Bibliográficos
Autores principales: Gray, Janine L., von Delft, Frank, Brennan, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204875/
https://www.ncbi.nlm.nih.gov/pubmed/30869179
http://dx.doi.org/10.1002/anie.201900585