A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays since there is not a significant visual difference be...

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Detalles Bibliográficos
Autores principales: Ramirez-Rios, Sacnicte, Michallet, Sophie, Peris, Leticia, Barette, Caroline, Rabat, Clotilde, Feng, Yangbo, Fauvarque, Marie-Odile, Andrieux, Annie, Sadoul, Karin, Lafanechère, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204994/
https://www.ncbi.nlm.nih.gov/pubmed/32425788
http://dx.doi.org/10.3389/fphar.2020.00543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204994/
https://www.ncbi.nlm.nih.gov/pubmed/32425788
http://dx.doi.org/10.3389/fphar.2020.00543

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