Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells

PURPOSE: Vacuolar protein sorting 35 (Vps35) mutations and protein dysfunction have been linked to the hyperphosphorylation and accumulation of tau protein in a number of central neurodegenerative disorders. The aims of the present study were to investigate the mechanism underlying the tau hyperphos...

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Detalles Bibliográficos
Autores principales: Gao, Ling, Xiao, Hang, Ai, Li-Qian-Yu, Chen, Chunlin, Lin, Sen, Zhou, Yuanguo, Ye, Jian, Liu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205187/
https://www.ncbi.nlm.nih.gov/pubmed/31995153
http://dx.doi.org/10.1167/iovs.61.1.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205187/
https://www.ncbi.nlm.nih.gov/pubmed/31995153
http://dx.doi.org/10.1167/iovs.61.1.1

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