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High-yield production of recombinant platelet factor 4 by harnessing and honing the gram-negative bacterial secretory apparatus
Platelet factor 4 is a cytokine released into the bloodstream by activated platelets where it plays a pivotal role in etiology and diagnosis of heparin-induced thrombocytopenia. Therefore, a sustainable source of recombinant PF4 with structural and functional similarity to its native form is urgentl...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205247/ https://www.ncbi.nlm.nih.gov/pubmed/32379796 http://dx.doi.org/10.1371/journal.pone.0232661 |