Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

Many proteins contain multiple folded domains separated by flexible linkers, and the ability to describe the structure and conformational heterogeneity of such flexible systems pushes the limits of structural biology. Using the three-domain protein TIA-1 as an example, we here combine coarse-grained...

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Detalles Bibliográficos
Autores principales: Larsen, Andreas Haahr, Wang, Yong, Bottaro, Sandro, Grudinin, Sergei, Arleth, Lise, Lindorff-Larsen, Kresten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205321/
https://www.ncbi.nlm.nih.gov/pubmed/32339173
http://dx.doi.org/10.1371/journal.pcbi.1007870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205321/
https://www.ncbi.nlm.nih.gov/pubmed/32339173
http://dx.doi.org/10.1371/journal.pcbi.1007870

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