Per-6-Thiolated Cyclodextrins: A Novel Type of Permeation Enhancing Excipients for BCS Class IV Drugs

[Image: see text] The purpose of the study was to develop a per-6-thiolated α-cyclodextrin (α-CD) by substituting all primary hydroxyl groups of α-CD with thiol groups and to assess its solubility-improving and permeation-enhancing properties for a BCS Class IV drug in vitro as well as in vivo. The...

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Detalles Bibliográficos
Autores principales: Asim, Mulazim Hussain, Nazir, Imran, Jalil, Aamir, Laffleur, Flavia, Matuszczak, Barbara, Bernkop-Schnürch, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205388/
https://www.ncbi.nlm.nih.gov/pubmed/31985207
http://dx.doi.org/10.1021/acsami.9b21335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205388/
https://www.ncbi.nlm.nih.gov/pubmed/31985207
http://dx.doi.org/10.1021/acsami.9b21335

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