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Diversity in kinetics correlated with structure in nano body-stabilized LacY
The structure of lactose permease, stabilized in a periplasmic open conformation by two Gly to Trp replacements (LacYww) and complexed with a nanobody directed against this conformation, provides the highest resolution structure of the symporter. The nanobody binds in a different manner than two oth...
Autores principales: | Kumar, Hemant, Finer-Moore, Janet, Smirnova, Irina, Kasho, Vladimir, Pardon, Els, Steyaert, Jan, Kaback, H. Ronald, Stroud, Robert M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205474/ https://www.ncbi.nlm.nih.gov/pubmed/32380514 http://dx.doi.org/10.1371/journal.pone.0232846 |
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