Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism

Mycobacterium tuberculosis (Mtb) encodes an exceptionally large number of toxin-antitoxin (TA) systems, supporting the hypothesis that TA systems are involved in pathogenesis. We characterized the putative Mtb Rv1044-Rv1045 TA locus structurally and functionally, demonstrating that it constitutes a...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Xia, Gao, Xiaopan, Zhu, Kaixiang, Yin, Han, Mao, Xujian, Wojdyla, Justyna Aleksandra, Qin, Bo, Huang, Hairong, Wang, Meitian, Sun, Yi-Cheng, Cui, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205606/
https://www.ncbi.nlm.nih.gov/pubmed/32382148
http://dx.doi.org/10.1038/s42003-020-0941-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205606/
https://www.ncbi.nlm.nih.gov/pubmed/32382148
http://dx.doi.org/10.1038/s42003-020-0941-1

Ejemplares similares