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A model-based approach for simulating adaptive clinical studies with surrogate endpoints used for interim decision-making

In clinical trials, when exploring multiple dose groups to establish efficacy and safety on one or more selected doses, adaptive designs with interim dose selection are often used for dropping less effective dose groups. When it takes a long time to observe primary outcomes, utilizing information on...

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Detalles Bibliográficos
Autores principales: Chen, Xiaotian, Hartford, Alan, Zhao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205753/
https://www.ncbi.nlm.nih.gov/pubmed/32395663
http://dx.doi.org/10.1016/j.conctc.2020.100562