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A model-based approach for simulating adaptive clinical studies with surrogate endpoints used for interim decision-making
In clinical trials, when exploring multiple dose groups to establish efficacy and safety on one or more selected doses, adaptive designs with interim dose selection are often used for dropping less effective dose groups. When it takes a long time to observe primary outcomes, utilizing information on...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205753/ https://www.ncbi.nlm.nih.gov/pubmed/32395663 http://dx.doi.org/10.1016/j.conctc.2020.100562 |