Acid‐sensing ion channel 3 blockade inhibits durovascular and nitric oxide‐mediated trigeminal pain

BACKGROUND AND PURPOSE: There is a major unmet need to develop new therapies for migraine. We have previously demonstrated the therapeutic potential of the acid‐sensing ion channel (ASIC) blockade in migraine, via an ASIC1 mechanism. ASIC3 is expressed in the trigeminal ganglion and its response is...

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Detalles Bibliográficos
Autores principales: Holton, Christopher M., Strother, Lauren C., Dripps, Isaac, Pradhan, Amynah A., Goadsby, Peter J., Holland, Philip R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205795/
https://www.ncbi.nlm.nih.gov/pubmed/31975427
http://dx.doi.org/10.1111/bph.14990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205795/
https://www.ncbi.nlm.nih.gov/pubmed/31975427
http://dx.doi.org/10.1111/bph.14990

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