Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C‐Src and inhibiting NF‐κB, MAPK and AKT pathways

Angelica sinensis (AS; Dang Gui), a traditional Chinese herb, has for centuries been used for the treatment of bone diseases, including osteoporosis and osteonecrosis. However, the effective ingredient and underlying mechanisms remain elusive. Here, we identified guaiacol as the active component of...

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Detalles Bibliográficos
Autores principales: Zhi, Xin, Fang, Chao, Gu, Yanqiu, Chen, Huiwen, Chen, Xiaofei, Cui, Jin, Hu, Yan, Weng, Weizong, Zhou, Qirong, Wang, Yajun, Wang, Yao, Jiang, Hao, Li, Xiaoqun, Cao, Liehu, Chen, Xiao, Su, Jiacan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205840/
https://www.ncbi.nlm.nih.gov/pubmed/32185887
http://dx.doi.org/10.1111/jcmm.15153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205840/
https://www.ncbi.nlm.nih.gov/pubmed/32185887
http://dx.doi.org/10.1111/jcmm.15153

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