A functional genetic screen defines the AKT-induced senescence signaling network

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival. Aberrant activation of this signaling network is an early driver of many sporadic human cancers. Paradoxically, sustained hyperactivation of the PI3K/AKT/mTORC1 pathway...

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Detalles Bibliográficos
Autores principales: Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D., George, Amee J., Sanij, Elaine, Hannan, Katherine M., Simpson, Kaylene J., Pearson, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205866/
https://www.ncbi.nlm.nih.gov/pubmed/31285545
http://dx.doi.org/10.1038/s41418-019-0384-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205866/
https://www.ncbi.nlm.nih.gov/pubmed/31285545
http://dx.doi.org/10.1038/s41418-019-0384-8

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