Mutant-selective topologic conversion facilitates selective degradation of a pathogenic prion isoform

Regulating protein import across the endoplasmic reticulum (ER) membrane occasionally results in the synthesis of topologically unnatural variants, and their accumulation often leads to proteotoxicity. However, since this is a regulated process, it is questionable whether the topological rearrangeme...

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Detalles Bibliográficos
Autores principales: Lee, Yumi, Eum, Hongsik, Lee, Duri, Lee, Sohee, Song, Youngsup, Kang, Sang-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205900/
https://www.ncbi.nlm.nih.gov/pubmed/31127199
http://dx.doi.org/10.1038/s41418-019-0354-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205900/
https://www.ncbi.nlm.nih.gov/pubmed/31127199
http://dx.doi.org/10.1038/s41418-019-0354-1

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