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Mutant-selective topologic conversion facilitates selective degradation of a pathogenic prion isoform
Regulating protein import across the endoplasmic reticulum (ER) membrane occasionally results in the synthesis of topologically unnatural variants, and their accumulation often leads to proteotoxicity. However, since this is a regulated process, it is questionable whether the topological rearrangeme...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205900/ https://www.ncbi.nlm.nih.gov/pubmed/31127199 http://dx.doi.org/10.1038/s41418-019-0354-1 |