OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

Methionine-1 (M1)-linked polyubiquitin chains conjugated by the linear ubiquitin chain assembly complex (LUBAC) control NF-κB activation, immune homoeostasis, and prevents tumour necrosis factor (TNF)-induced cell death. The deubiquitinase OTULIN negatively regulates M1-linked polyubiquitin signalli...

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Detalles Bibliográficos
Autores principales: Damgaard, Rune Busk, Jolin, Helen E., Allison, Michael E. D., Davies, Susan E., Titheradge, Hannah L., McKenzie, Andrew N. J., Komander, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206033/
https://www.ncbi.nlm.nih.gov/pubmed/32231246
http://dx.doi.org/10.1038/s41418-020-0532-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206033/
https://www.ncbi.nlm.nih.gov/pubmed/32231246
http://dx.doi.org/10.1038/s41418-020-0532-1

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