SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity

Lipophagy is a lysosomal lipolytic pathway that complements the actions of cytosolic neutral lipases. Chaperon-mediated autophagy (CMA) triggers lipid droplets (LDs) breakdown, to initiate lipolysis via either cytosolic lipases or macroautophagy. SIRT3, a mitochondrial NAD(+)-dependent deacetylase,...

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Detalles Bibliográficos
Autores principales: Zhang, Tian, Liu, Jingxin, Shen, Shengnan, Tong, Qiang, Ma, Xiaojun, Lin, Ligen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206074/
https://www.ncbi.nlm.nih.gov/pubmed/31160717
http://dx.doi.org/10.1038/s41418-019-0356-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206074/
https://www.ncbi.nlm.nih.gov/pubmed/31160717
http://dx.doi.org/10.1038/s41418-019-0356-z

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