RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

The kinase RIP1 acts in multiple signaling pathways to regulate inflammatory responses and it can trigger both apoptosis and necroptosis. Its kinase activity has been implicated in a range of inflammatory, neurodegenerative, and oncogenic diseases. Here, we explore the effect of inhibiting RIP1 gene...

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Detalles Bibliográficos
Autores principales: Patel, Snahel, Webster, Joshua D., Varfolomeev, Eugene, Kwon, Youngsu C., Cheng, Jason H., Zhang, Juan, Dugger, Debra L., Wickliffe, Kate E., Maltzman, Allie, Sujatha-Bhaskar, Swathi, Bir Kohli, Pawan, Ramaswamy, Sreema, Deshmukh, Gauri, Liederer, Bianca M., Fong, Rina, Hamilton, Greg, Lupardus, Patrick, Caplazi, Patrick, Lee, Wyne P., van Lookeren Campagne, Menno, Johnson, Adam, McKenzie, Brent S., Junttila, Melissa R., Newton, Kim, Vucic, Domagoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206119/
https://www.ncbi.nlm.nih.gov/pubmed/31101885
http://dx.doi.org/10.1038/s41418-019-0347-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206119/
https://www.ncbi.nlm.nih.gov/pubmed/31101885
http://dx.doi.org/10.1038/s41418-019-0347-0

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