T-cell receptor signal strength and epigenetic control of Bim predict memory CD8(+) T-cell fate

Most effector CD8(+) T cells die, while some persist and become either “effector” (T(EM)) or “central” (T(CM)) memory T cells. Paradoxically, effector CD8(+) T cells with greater memory potential have higher levels of the pro-apoptotic molecule Bim. Here, we report, using a novel Bim-mCherry knock-i...

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Detalles Bibliográficos
Autores principales: Li, Kun-Po, Ladle, Brian H., Kurtulus, Sema, Sholl, Allyson, Shanmuganad, Sharmila, Hildeman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206134/
https://www.ncbi.nlm.nih.gov/pubmed/31558776
http://dx.doi.org/10.1038/s41418-019-0410-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206134/
https://www.ncbi.nlm.nih.gov/pubmed/31558776
http://dx.doi.org/10.1038/s41418-019-0410-x

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