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T-cell receptor signal strength and epigenetic control of Bim predict memory CD8(+) T-cell fate
Most effector CD8(+) T cells die, while some persist and become either “effector” (T(EM)) or “central” (T(CM)) memory T cells. Paradoxically, effector CD8(+) T cells with greater memory potential have higher levels of the pro-apoptotic molecule Bim. Here, we report, using a novel Bim-mCherry knock-i...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206134/ https://www.ncbi.nlm.nih.gov/pubmed/31558776 http://dx.doi.org/10.1038/s41418-019-0410-x |