Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

BACKGROUND: Silica nanoparticles (nanoSiO(2)) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO(2) has been recently related to abnormal calcium handling and energetic failure in ca...

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Detalles Bibliográficos
Autores principales: Lozano, Omar, Silva-Platas, Christian, Chapoy-Villanueva, Héctor, Pérez, Baruc E., Lees, Jarmon G., Ramachandra, Chrishan J. A., Contreras-Torres, Flavio F., Lázaro-Alfaro, Anay, Luna-Figueroa, Estefanía, Bernal-Ramírez, Judith, Gordillo-Galeano, Aldemar, Benitez, Alfredo, Oropeza-Almazán, Yuriana, Castillo, Elena C., Koh, Poh Ling, Hausenloy, Derek J., Lim, Shiang Y., García-Rivas, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206702/
https://www.ncbi.nlm.nih.gov/pubmed/32381100
http://dx.doi.org/10.1186/s12989-020-00346-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206702/
https://www.ncbi.nlm.nih.gov/pubmed/32381100
http://dx.doi.org/10.1186/s12989-020-00346-2

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