Deficiency of TGR5 exacerbates immune-mediated cholestatic hepatic injury by stabilizing the β-catenin destruction complex

Intrahepatic cholestasis induced by drug toxicity may cause cholestatic hepatic injury (CHI) leading to liver fibrosis and cirrhosis. The G protein-coupled bile acid receptor 1 (TGR5) is a membrane receptor with well-known roles in the regulation of glucose metabolism and energy homeostasis. However...

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Detalles Bibliográficos
Autores principales: Rao, Jianhua, Yang, Chao, Yang, Shikun, Lu, Hao, Hu, Yuanchang, Lu, Ling, Cheng, Feng, Wang, Xuehao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206975/
https://www.ncbi.nlm.nih.gov/pubmed/31930324
http://dx.doi.org/10.1093/intimm/dxaa002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206975/
https://www.ncbi.nlm.nih.gov/pubmed/31930324
http://dx.doi.org/10.1093/intimm/dxaa002

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