Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ALS/FTD is rescued by SV2 replenishment

The most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an intronic hexanucleotide repeat expansion in the C9orf72 gene. In disease, RNA transcripts containing this expanded region undergo repeat‐associated non‐AUG translation to produce dipeptide repeat pro...

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Detalles Bibliográficos
Autores principales: Jensen, Brigid K, Schuldi, Martin H, McAvoy, Kevin, Russell, Katelyn A, Boehringer, Ashley, Curran, Bridget M, Krishnamurthy, Karthik, Wen, Xinmei, Westergard, Thomas, Ma, Le, Haeusler, Aaron R, Edbauer, Dieter, Pasinelli, Piera, Trotti, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207170/
https://www.ncbi.nlm.nih.gov/pubmed/32347002
http://dx.doi.org/10.15252/emmm.201910722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207170/
https://www.ncbi.nlm.nih.gov/pubmed/32347002
http://dx.doi.org/10.15252/emmm.201910722

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