SUN-140 TMEPAI Inhibits SMAD 2/3 Mediated Muscle Wasting

Inhibition of myostatin and activin activity using ligand traps, such as soluble receptors, follistatin and propeptides, can markedly increase skeletal muscle mass in healthy mice and ameliorate wasting in models of cancer cachexia and muscular dystrophy. Though effective, clinical translation of th...

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Detalles Bibliográficos
Autores principales: Kharoud, Swati, Walton, Kelly Louise, Hagg, Adam, Goodchild, Georgia, Chen, Justin, Thomson, Rachel, Qian, Hongwei, Gregorevic, Paul, Harrison, Craig Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207501/
http://dx.doi.org/10.1210/jendso/bvaa046.1585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207501/
http://dx.doi.org/10.1210/jendso/bvaa046.1585

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