OR31-05 Emergence of Ovarian Hyperandrogenism and Luteal Insufficiency Following ESR1 Knockdown in the Mediobasal Hypothalamus of Adult Female Rhesus Monkeys

Diminished estradiol (E2) negative feedback action by neuronal ESR1 in the arcuate nucleus (ARC) of the mediobasal hypothalamus (MBH) is hypothesized to cause gonadotropin-releasing hormone (GnRH) hypersecretion, and thus LH excess, contributing to ovarian hyperandrogenism in polycystic ovary syndro...

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Detalles Bibliográficos
Autores principales: Levine, Jon E, Greinwald, Emily P, Felton, Jesi A, Flowers, Matthew T, Willging, Molly M, Shapiro, Robert A, Keen, Kim L, Terasawa, Ei, Uhlrich, Daniel J, Abbott, David Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Reproductive Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207541/
http://dx.doi.org/10.1210/jendso/bvaa046.1320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207541/
http://dx.doi.org/10.1210/jendso/bvaa046.1320

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