SAT-421 Novel Role of Chloroquine and Hydroxychloroquine in Graves’ Orbitopathy Therapy by Targeting Orbital Fibroblasts

Abstract: Context: Graves’ orbitopathy (GO) presents with infiltrative exophthalmos due to excessive proliferation, adipogenesis and glycosaminoglycans production of orbital fibroblasts (OFs). There are few therapies potent for proptosis. Intervention in autophagy of OFs could be a potential therapy...

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Detalles Bibliográficos
Autores principales: Guo, Yan, Li, Hai, Chen, Xueying, Guan, Hongyu, He, Xiaoying, Chen, Yuxin, Xiao, Haipeng, Li, Yanbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Thyroid
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207710/
http://dx.doi.org/10.1210/jendso/bvaa046.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207710/
http://dx.doi.org/10.1210/jendso/bvaa046.016

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