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OR28-03 Drug Repurposing Identifies Inhibitors of the Proteostasis Network to Augment Radioiodine Uptake in Combinatorial Approaches Targeting Thyroid Cancer
New combinatorial drug strategies are urgently needed to improve radioiodine (RAI) uptake and efficiently ablate thyroid cancer cells, thereby reducing the risk of recurrent disease. Drug repurposing offers the promise of identifying already approved compounds capable of inducing sodium iodide sympo...
Autores principales: | Read, Martin L, Brookes, Katie, Fletcher, Alice, Thornton, Caitlin E M, Alshahrani, Mohammed, Khan, Rashida, Nieto, Hannah R, Adcock, Holly V, Webster, Jamie R M, Cox, Liam, Alderwick, Luke J, Boelaert, Kristien, Smith, Vicki E, McCabe, Christopher J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208217/ http://dx.doi.org/10.1210/jendso/bvaa046.2135 |
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