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SAT-742 Characterising the Metabolism, Glucuronidation and Sulfation of C11-oxy C(19) Steroids

The metabolism of 11β-hydroxyandrostenedione (11OHA4), a major adrenal C(19) steroid, was first characterised in our in vitro prostate models showing that 11OHA4, catalysed by 11βHSDs, 17βHSDs and 5α-reductases, yields potent androgens, 11keto-testosterone (11KT) and 11keto-dihydrotestosterone (11KD...

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Detalles Bibliográficos
Autores principales: Toit, Therina Du, Swart, Amanda C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208218/
http://dx.doi.org/10.1210/jendso/bvaa046.792