OR05-05 Lethal ERα-Dependent Hyperactivation of the Unfolded Protein Response Induces Complete Regression Without Recurrence of Primary and Metastatic Breast Cancer

Metastatic estrogen receptor α (ERα) positive breast cancer is presently incurable and most patients die within 7 years. From a medicinal chemistry program, we identified a novel small molecule that acts through ERα to kill breast cancer cells and often induces complete regression without recurrence...

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Detalles Bibliográficos
Autores principales: Duraki, Darjan, Boudreau, Matthew W, Wang, Lawrence, Mao, Chengjian, Tang, Bingtao, Ma, Liqian, Roy, Edward J, Fan, Timothy M, Park, Ben Ho, Nelson, Erik R, Hergenrother, Paul J, Shapiro, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208387/
http://dx.doi.org/10.1210/jendso/bvaa046.653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208387/
http://dx.doi.org/10.1210/jendso/bvaa046.653

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