Cargando…

OR05-05 Lethal ERα-Dependent Hyperactivation of the Unfolded Protein Response Induces Complete Regression Without Recurrence of Primary and Metastatic Breast Cancer

Metastatic estrogen receptor α (ERα) positive breast cancer is presently incurable and most patients die within 7 years. From a medicinal chemistry program, we identified a novel small molecule that acts through ERα to kill breast cancer cells and often induces complete regression without recurrence...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duraki, Darjan, Boudreau, Matthew W, Wang, Lawrence, Mao, Chengjian, Tang, Bingtao, Ma, Liqian, Roy, Edward J, Fan, Timothy M, Park, Ben Ho, Nelson, Erik R, Hergenrother, Paul J, Shapiro, David J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Tumor Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208387/ http://dx.doi.org/10.1210/jendso/bvaa046.653

Ejemplares similares

ERa-Dependent Lethal Hyperactivation of the Anticipatory Unfolded Protein Response Induces Complete Regression Without Recurrence of Advanced Breast Cancer
por: Duraki, Darjan, et al.
Publicado: (2021)

OR16-06 A Novel Pathway Controlling Anticancer Drug Induced Immunogenic Necrosis In ERα Positive Cancer Cells
por: Zhu, Junyao, et al.
Publicado: (2023)

OR16-1 How Strong and Sustained Activation of the Estrogen Receptor-mediated Anticipatory Unfolded Protein Response Kills Breast and Ovarian Cancer Cells
por: Boudreau, Matthew, et al.
Publicado: (2022)

OR05-01 Myeloid Cell Intrinsic NR0B2 Inhibits Regulatory T Cell Expansion Within The Tumor Microenvironment: Potential Novel Strategy For Breast Cancer Immunotherapy
por: Vidana Gamage, Hashni Epa, et al.
Publicado: (2023)

OR05-05 A Novel Model Of Prostate Cancer Suggests Enzalutamide Functions Through The Immune System To Diminish Castration Resistant And Metastatic Growth
por: Kregel, Steven
Publicado: (2023)

OR05-01 Small Heterodimer Partner Modulates Antigen Presenting Myeloid Cells to Impair Regulatory T Cell Expansion, Promoting Anti-Tumor Immunity in Models of Breast Cancer
por: Shahoei, Sayyed Hamed, et al.
Publicado: (2020)

OR05-03 Treatment Of Parathyroid Neoplasia By Pharmacologic cdk4/6 Inhibition
por: Costa-Guda, Jessica, et al.
Publicado: (2023)

Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response
por: Zheng, Xiaobin, et al.
Publicado: (2016)

OR16-05 25-Hydroxycholesterol Mediates The Effects Of Dyslipidemia On Triple Negative Breast Cancer Metastasis
por: Etella, Abora, et al.
Publicado: (2023)

OR05-04 Steroid Receptor Co-Activators Complexes Cooperate with Progesterone Receptors (PR) to Reprogram Metabolic Pathways that Drive Therapy Resistant Populations in ER+ Breast Cancer
por: Truong, Thu H, et al.
Publicado: (2020)

RF05 | PSUN341 Role of sirtuins in breast cancer cells response to Fulvestrant
por: Sengupta, Surojeet, et al.
Publicado: (2022)

OR05-06 The Androgen Receptor Is a Tumour Suppressor in Estrogen Receptor Positive Breast Cancer
por: Hickey, Theresa E, et al.
Publicado: (2020)

OR05-06 Histone Deacetylase Inhibitor, Panobinostat, In Combination With A Smac-mimetic For The Treatment Of Ovarian Granulosa Cell Tumours
por: Chu, Simon, et al.
Publicado: (2023)

RF05 | PSUN365 Insulinoma: A Case Report of a Rare Functioning Neuroendocrine Tumor
por: Pescador, Antonio, et al.
Publicado: (2022)

OR05-02 The IGFBP-3/IGFBP-3 Receptor Axis Is a New Therapeutic Target for Triple Negative Breast Cancer
por: Cai, Qing, et al.
Publicado: (2020)

RARE-05. MOLECULAR HETEROGENEITY OF PEDIATRIC CHOROID PLEXUS CARCINOMAS
por: Zaytseva, Margarita, et al.
Publicado: (2023)

RF05 | PSUN364 A Rare Case of Bilateral Parathyroid Carcinoma in the Setting of Multiple Endocrine Neoplasia Type 1
por: Kesavan Chary, Priyanka, et al.
Publicado: (2022)

OR05-02 Silencing Of Adenylosuccinate Lyase Impairs Growth And Perturbs Mitochondrial Function Of Endocrine Therapy Resistant Breast Cancer Cells
por: Yadav, Anil K, et al.
Publicado: (2023)

EMBR-05. THE TENTATIVE APPLICATION OF EN BLOC CONCEPT IN THE PEDIATRIC BRAIN TUMOR: EXPERIENCE FROM A LARGE PEDIATRIC CENTER IN CHINA
por: Cao, Liangliang, et al.
Publicado: (2021)

RF05 | PSUN358 ANPEP: A potential regulator of tumor cell - macrophage metabolic interactions in prostate cancer of African American men
por: Yamoah, Kosj, et al.
Publicado: (2022)

OR05-04 Growth Hormone Receptor Antagonism Markedly Improves Therapeutic Response In Mouse Models Of Melanoma, Liver Cancer, Pancreatic Cancer And Cholangiocarcinoma
por: Basu, Reetobrata, et al.
Publicado: (2023)

RF05 | PSUN354 Associations between immune-related thyroid dysfunction and efficacy of immune checkpoint inhibitors – A systematic review and meta-analysis
por: Cheung, Yee-Ming Melody, et al.
Publicado: (2022)

RF05 | PSUN357 Scaffold Protein IQGAP1 Bridges Proliferative Signaling Between Bile Acids and the Cellular Microenvironment to Mediate Hepatic Cell Proliferation
por: Anakk, Sayeepriyadarshini, et al.
Publicado: (2022)

EXM-86-05: 07/05/1986
por: Malandain, E
Publicado: (1986)

Exchange bias effect in polycrystalline Bi(0.5)Sr(0.5)Fe(0.5)Cr(0.5)O(3) bulk
por: Li, S. Z., et al.
Publicado: (2023)

ATRT-05. REPURPOSED ANTI-MALARIAL QUINACRINE ACTIVATES P53 AND INHIBITS ATRT TUMORIGENICITY
por: Kaur, Harpreet, et al.
Publicado: (2021)

SPINAL TUMORS-05 CERVICAL DENDRITIC FOLLICULAR SARCOMA: ABOUT A CASE WITH LITERATURE REVIEW
por: Mala, Zeus, et al.
Publicado: (2023)

Microstructural Design of Ba(0.5)La(0.5)Co(0.5)Fe(0.5)O(3) Perovskite Ceramics
por: Gierszewska, Daria, et al.
Publicado: (2021)

EXM-87-05
por: Martucci, P, et al.
Publicado: (1987)

RARE-05. Legal degree of disability in childhood-craniopharyngioma survivors during long-term follow-up – results of the HIT-ENDO study
por: Boekhoff, Svenja, et al.
Publicado: (2022)

ETMR-05. Single-cell transcriptomics of ETMR reveals developmental cellular programs and tumor-pericyte communications in the microenvironment
por: de Faria, Flavia W, et al.
Publicado: (2022)

Structural Insight into La(0.5)Ca(0.5)Mn(0.5)Co(0.5)O(3) Decomposition in the Methane Combustion Process
por: Nikolaeva, Olga, et al.
Publicado: (2021)

Crystal chemistry and compressibility of Fe(0.5)Mg(0.5)Al(0.5)Si(0.5)O(3) and FeMg(0.5)Si(0.5)O(3) silicate perovskites at pressures up to 95 GPa
por: Koemets, Iuliia, et al.
Publicado: (2023)

The effect of Timolol 0.5% on the correction of myopic regression after LASIK
por: Qi, Hong, et al.
Publicado: (2017)

ICIS05 CONFERENCE
por: Lau, C, et al.
Publicado: (02/1)

Exm 93-05
por: Benincasa, G.P, et al.
Publicado: (1993)

SAT-340 27-Hydroxycholesterol Acts on Myeloid Cells to Inhibit T Cell Expansion
por: Ma, Liqian, et al.
Publicado: (2019)

Near-infrared emitting CdTe(0.5)Se(0.5)/Cd(0.5)Zn(0.5)S quantum dots: synthesis and bright luminescence
por: Yang, Ping, et al.
Publicado: (2012)

Especificación para estructuras de mampostería (ACI 530.1-05/ASCE 6-05/TMS 602-05)
Publicado: (2007)

LEAR MD report: Oxygen ions storage tests (05-10/05/92)
por: Baird, S, et al.
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_44ibs2cbsr6p4ieh6195ioh950