SAT-LB126 Metformin Attenuates Sodium Retention and Blood Pressure in Hypertensive Diabetic Mice by Reducing the Phosphorylation of Renal NCC and Its Association With the Actin Cytoskeleton

Metformin is the first-line drug in the treatment of type 2 diabetes mellitus. The aim of this work was to evaluate the efficacy of metformin treatment in reducing blood pressure and investigate the molecular mechanism using a preclinical animal model. Adult male and female diabetic db/db mice with...

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Detalles Bibliográficos
Autores principales: Gholam, Mohammed F, Waleed, Alina, Tuna, Kubra M, Carson-Marino, Morgan, Chacko, Kevin M, Malik, Zeeshan S, Schramm, Whitney C, Lopez, Juliana V Pena, Alli, Abdel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diabetes Mellitus and Glucose Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209095/
http://dx.doi.org/10.1210/jendso/bvaa046.2201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209095/
http://dx.doi.org/10.1210/jendso/bvaa046.2201

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