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SAT-283 Generation of a Long-Acting Human Growth Hormone Receptor Antagonist by Site-Specific Pegylation

Growth hormone (GH) is a peptide hormone that mediates actions through binding to a cell surface GH receptor (GHR), activating key signalling pathways including the JAK/STAT pathway. Excess GH secretion leads to acromegaly and tumoral expression has been implicated in cancer progression, suggesting...

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Detalles Bibliográficos
Autores principales: Wang, Yue, Langley, Ries J, Tamshen, Kyle, Maynard, Heather D, Jamieson, Stephen M F, Perry, Jo K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209340/
http://dx.doi.org/10.1210/jendso/bvaa046.408