SUN-125 Phase Ib Study of Dual Therapy with an Aromatase Inhibitor Exemestane and Carboplatin-Based Therapy for Postmenopausal Women with Advanced Non-Small Cell Lung Cancer

Objectives: Estrogen receptors (ER-alpha, ER-beta) and aromatase (key enzyme for estrogen synthesis) are expressed in most human non-small cell lung cancers (NSCLCs). High intratumoral estrogens and elevated aromatase in NSCLC are reported to predict poor clinical outcome. In vitro, estrogen stimula...

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Detalles Bibliográficos
Autores principales: Young, Patricia A, Marquez-Garban, Diana C, Goodglick, Lee, Noor, Zorawar S, Moatamed, Neda, Elashoff, David, Grogan, Tristan, Romero, Tahmineh, Sasano, Hironobu, Saito, Ryoko, Rausch, Rebecca, Hamilton, Nalo, Dubinett, Steven M, Garon, Edward, Pietras, Richard J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209401/
http://dx.doi.org/10.1210/jendso/bvaa046.695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209401/
http://dx.doi.org/10.1210/jendso/bvaa046.695

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