OR34-02 Somatic Transmembrane Domain Mutations of a Cell Adhesion Molecule, CADM1, Cause Primary Aldosteronism by Preventing Gap Junction Communication Between Adrenocortical Cells

Primary Aldosteronism (PA) is the commonest curable cause of hypertension. Whole exome sequencing (WES) in 2011 and 2013 identified common somatic mutations in genes regulating membrane polarisation in 60–80% of aldosterone-producing adenomas (APA). We undertook WES on 39 consecutive APAs in search...

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Detalles Bibliográficos
Autores principales: Wu, Xilin, Garg, Sumedha, Cabrera, Claudia P, Azizan, Elena, Zhou, Junhua, Mein, Chaz, Wozniak, Eva, Zhao, Wanfeng, Marker, Alison, Buss, Folma, Murakami, Masanori, Reincke, Martin, Takaoka, Yutaka, Beuschlein, Felix, Akihiko, Ito, Brown, Morris Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Cardiovascular Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209540/
http://dx.doi.org/10.1210/jendso/bvaa046.492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209540/
http://dx.doi.org/10.1210/jendso/bvaa046.492

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