Cargando…

OR24-01 Mutational Study of the GPR119 Receptor Binding Site

The GPR119 receptor, a class A G-protein coupled receptor located in the pancreatic β cells, induces insulin production when activated. Due to its specific activity, the pharmaceutical industry has identified GPR119 as a target for the treatment for type 2 diabetes. The lack of a GRP119 crystal stru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosales, Matthew D, Dean, Frank, Kotsikorou, Evangelia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genetics and Development (including Gene Regulation)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209689/ http://dx.doi.org/10.1210/jendso/bvaa046.1659

Ejemplares similares

SAT-712 Computational Study of the Effect of Androgen Receptor BF 3 Site Mutations on DDE Binding
por: Chowdhury, Muniruzzaman, et al.
Publicado: (2020)

SAT-718 Inhibition of Androgen Receptor Activity by DDE Is Affected by Mutations in the BF3 Site
por: Lozano, Andrea, et al.
Publicado: (2020)

Differential Activity and Utilization of Glucocorticoid Receptor Binding Sites Yields Transcriptional Heterogeneity
por: Hoffman, Jackson Andrew, et al.
Publicado: (2021)

SUN-724 Associations of GPR174 and ITM2A Genes on X Chromosome with Early Onset Autoimmune Thyroid Disease in Korean
por: Lee, Nayeong, et al.
Publicado: (2020)

OR24-02 Identification of Membrane Proteins That Enhance the Responsiveness of the Ghrelin Receptor
por: Prins, Karina, et al.
Publicado: (2020)

OR24-07 Fetal Sex Impacts First Trimester Maternal-Fetal Communication in Humans
por: Gonzalez, Tania L, et al.
Publicado: (2020)

OR24-04 Ovarian Follicle Survival Is Determined by Follicle-Stimulating Hormone Receptor (FSHR) and Estrogen Receptor (GPER) Heteromers
por: Casarini, Livio, et al.
Publicado: (2020)

OR24-06 USP8 Genetic Variants May Contribute to the Development of Bilateral Adrenal Hyperplasia and ACTH-Independent Cushing Syndrome
por: Settas, Nikolaos, et al.
Publicado: (2020)

OR24-03 GRK2 Mediates Beta-Adrenergic Receptor Crosstalk to Enhanced Adrenocortical AngII-Dependent Aldosterone Production
por: Lymperopoulos, Anastasios, et al.
Publicado: (2020)

OR24-05 Identifying Regulatory Elements Within a Novel Enhancer of FSHB Containing Two PCOS-Associated Single Nucleotide Polymorphisms
por: Bohaczuk, Stephanie C, et al.
Publicado: (2020)

SUN-046 Identification of Clinical Predictors for Detection of Mutations in Multiple Endocrine Neoplasia Type 1
por: Urtremari, Betsaida, et al.
Publicado: (2019)

SUN-LB133 Analysis of Clinical Characteristics and Gene Mutation in Four Cases of Gitelman Syndrome
por: Yao, Bin
Publicado: (2020)

SUN-047 Germline and Somatic Mutations in DICER1 Gene Associated with Different Hereditary Tumours in Paediatric Patients
por: Trobo, Sofia, et al.
Publicado: (2019)

Novel Mutations in FGFR1 Causing Idiopathic Hypogonadotropic Hypogonadism: A Cohort Study in Eastern Indian Population
por: Baidya, Arjun, et al.
Publicado: (2021)

SUN-035 Performance of Mutation Pathogenicity Prediction Tools on Missense Variants Associated with 46XY Disorders of Sex Development
por: Montenegro, Luciana, et al.
Publicado: (2019)

SUN-LB132 Frequency and Impact of Mutations in Tumor Suppressor Gene CDC73 in General Population and Malignant Tumors
por: Li, Yulong, et al.
Publicado: (2020)

OR15-4 Long-Term Follow-Up of a Female with a Mutation in the Estrogen Receptor Alpha (ESR1) Gene
por: Brakta, Soumia, et al.
Publicado: (2019)

MON-717 Novel GLI2 Mutations Identified in Pediatric Patients with Combined Pituitary Hormone Deficiency: One Gene, Various Genotypes
por: Vishnopolska, Sebastian A, et al.
Publicado: (2020)

OR15-3 Extreme Phenotypic Variability of a Novel Mutation of MEN1 Gene in a Family with 14 Carriers across 3 Generations
por: Chaves, Carolina, et al.
Publicado: (2019)

SUN-714 Phenotype of Patients Carrying the c.709(-7-2)del PRKAR1A Mutation in a Large Cohort of 41 Patients
por: Abderrahmane, Fatimetou, et al.
Publicado: (2020)

SUN-LB006 Skeletal Muscle Krüppel-Like Factor 15 and PPARd Cooperate to Regulate Skeletal Muscle Lipid Metabolism
por: Fan, Liyan, et al.
Publicado: (2019)

SUN-034 Genetic Diagnosis of Congenital Isolated or Combined Growth Hormone Deficiency by Massive Parallel Sequencing Using a Target Gene Panel
por: NAKAGUMA, MARILENA, et al.
Publicado: (2019)

OR15-2 A Novel Upstream Enhancer Acts Synergistically with GnRH and Activin to Increase FSHβ Transcription
por: Bohaczuk, Stephanie, et al.
Publicado: (2019)

OR15-5 Human Sex Determination at the Edge of Ambiguity: Impaired SRY Phosphorylation Attenuates Expression of the Male Program
por: Chen, Yen-Shan, et al.
Publicado: (2019)

OR15-6 Epigenetic Differences in First Trimester Pregnancies Conceived with Infertility
por: Gonzalez, Tania, et al.
Publicado: (2019)

OR15-1 Identification and Functional Characterization of Tumor-specific X-linked Genes In Breast Cancer
por: Choudhari, Ramesh, et al.
Publicado: (2019)

SUN-033 RNA-Seq Analysis of Ovariectomy-Induced Changes in Mouse Liver Reveals New Targets for Menopause-Associated Metabolic Derangement
por: Stokar, Joshua, et al.
Publicado: (2019)

SUN-045 Resilience in the Regulation of the Unfolded Protein Response across Tissues and Species
por: Soltanmohamadi, Elham, et al.
Publicado: (2019)

SUN-LB009 Epigenetic Changes in Response to Metabolic Modifiers in Late Life: Exercise, High Fat Diet, and Angiotenin1-7 Effects on Metabolic Health and DNA Methylation in Frail Old Mice
por: Shefer, Gabi, et al.
Publicado: (2019)

SUN-036 SLC16A11 Gene Expression In Mothers With And Without Gestational Diabetes And Their Offspring Umbilical Cord Blood.
por: Marrero-Rodríguez, Daniel, et al.
Publicado: (2019)

SUN-044 Methylation Status and Gene Expression of Steroidogenic Enzymes in Benign Adrenocortical Tumors
por: Di Dalmazi, Guido, et al.
Publicado: (2019)

SUN-029 Circular RNA Profile of Parathyroid Neoplasms: Analysis of Co-Expression Networks of Circular RNAs and mRNAs
por: Hu, Ya, et al.
Publicado: (2019)

SUN-032 Exome Sequencing Reveals that Pathogenic RET Variants Occur at Higher Prevalence Than Previously Recognized: Data from a US Health System Biobank
por: Guzman, Heidi, et al.
Publicado: (2019)

SUN-031 Quantification of Pooled Libraries for Optimizing Cluster Density in Next Generation Sequencing
por: Narcizo, Amanda, et al.
Publicado: (2019)

SUN-LB007 The Mouse AgRP Gene Has Three Promoters: Differential Regulation by Nutritional States
por: Ifebi, Bruno, et al.
Publicado: (2019)

SUN-030 Expression Profiles of Short RNAs in Mouse Serum Employing Endocrine Organs as Controls
por: Habib, Tanwir, et al.
Publicado: (2019)

SUN-037 Diagnosis Challenge in Type 4 Familial Partial Lipodystrophic Syndrome
por: Vantyghem, Marie-Christine, et al.
Publicado: (2019)

SUN-050 The Evolutionarily Conserved Function of COUP-TF Genes in the Differentiation of Photoreceptor Cells in the Retina
por: Zhu, Jian, et al.
Publicado: (2019)

SUN-042 Loss of the 18-Kda Translocator Protein Tspo Destabilizes Cholesterol Homeostasis in a Hepatic Steatosis Cell Model
por: Li, Yuchang, et al.
Publicado: (2019)

SUN-040 Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) Syndrome: Prospective Screening of Asplenism and Pneumonitis in a Cohort of 25 Patients
por: Humbert, Linda, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9sa2u3ji5gu2ssg6j7f8tf0mb6