OR12-07 Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many Ligand-Induced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain

Although most estrogen receptor alpha (ERα)-positive breast cancers initially respond well to endocrine therapies using aromatase inhibitors (AIs) or antiestrogens, after varying time periods the cancer frequently recurs as metastatic disease. A significant fraction of these recurrences are driven b...

Descripción completa

Detalles Bibliográficos
Autores principales: Nwachukwu, Jerome, Min, Jian, Srinivasan, Sathish K, Rangarajan, Erumbi, Guillen, Valeria Sanabria, Ziegler, Yvonne, Carlson, Kathryn, Hou, Yingwei, Kim, Sung Hoon, Izard, Tina, Houtman, Rene, Katzenellenbogen, Benita S, Nettles, Kendall W, Katzenellenbogen, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Steroid Hormones and Receptors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209757/
http://dx.doi.org/10.1210/jendso/bvaa046.249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209757/
http://dx.doi.org/10.1210/jendso/bvaa046.249

Ejemplares similares