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OR12-07 Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many Ligand-Induced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain

Although most estrogen receptor alpha (ERα)-positive breast cancers initially respond well to endocrine therapies using aromatase inhibitors (AIs) or antiestrogens, after varying time periods the cancer frequently recurs as metastatic disease. A significant fraction of these recurrences are driven b...

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Detalles Bibliográficos
Autores principales:	Nwachukwu, Jerome, Min, Jian, Srinivasan, Sathish K, Rangarajan, Erumbi, Guillen, Valeria Sanabria, Ziegler, Yvonne, Carlson, Kathryn, Hou, Yingwei, Kim, Sung Hoon, Izard, Tina, Houtman, Rene, Katzenellenbogen, Benita S, Nettles, Kendall W, Katzenellenbogen, John A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Steroid Hormones and Receptors
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209757/ http://dx.doi.org/10.1210/jendso/bvaa046.249

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