Programming PAM antennae for efficient CRISPR-Cas9 DNA editing

Bacterial CRISPR-Cas9 nucleases have been repurposed as powerful genome editing tools. Whereas engineering guide RNAs or Cas nucleases have proven to improve the efficiency of CRISPR editing, modulation of protospacer-adjacent motif (PAM), indispensable for CRISPR, has been less explored. Here, we d...

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Detalles Bibliográficos
Autores principales: Wang, Fei, Hao, Yaya, Li, Qian, Li, Jiang, Zhang, Honglu, Zhang, Xueli, Wang, Lihua, Bustamante, Carlos, Fan, Chunhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209990/
https://www.ncbi.nlm.nih.gov/pubmed/32494703
http://dx.doi.org/10.1126/sciadv.aay9948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209990/
https://www.ncbi.nlm.nih.gov/pubmed/32494703
http://dx.doi.org/10.1126/sciadv.aay9948

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