Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing

BACKGROUND: Sam68, an RNA-binding protein, exerts oncogenic functions in several types of cancer. However, the specific functions and mechanisms of Sam68 in colorectal cancer (CRC) had not been previously clarified. Pyruvate kinase muscle (PKM)2 is the key rate-limiting enzyme in glycolysis, and PKM...

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Detalles Bibliográficos
Autores principales: Zhao, Jing, Li, Jiuming, Hassan, Waseem, Xu, Dongyan, Wang, Xue, Huang, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210197/
https://www.ncbi.nlm.nih.gov/pubmed/32395503
http://dx.doi.org/10.21037/atm.2020.03.108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210197/
https://www.ncbi.nlm.nih.gov/pubmed/32395503
http://dx.doi.org/10.21037/atm.2020.03.108

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