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Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing
BACKGROUND: Sam68, an RNA-binding protein, exerts oncogenic functions in several types of cancer. However, the specific functions and mechanisms of Sam68 in colorectal cancer (CRC) had not been previously clarified. Pyruvate kinase muscle (PKM)2 is the key rate-limiting enzyme in glycolysis, and PKM...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
AME Publishing Company
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210197/ https://www.ncbi.nlm.nih.gov/pubmed/32395503 http://dx.doi.org/10.21037/atm.2020.03.108 |