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Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation
DNA methyltransferase DNMT3A is essential for establishment of mammalian DNA methylation during development. The R882H DNMT3A is a hotspot mutation in acute myeloid leukemia (AML) causing aberrant DNA methylation. However, how this mutation affects the structure and function of DNMT3A remains unclea...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210271/ https://www.ncbi.nlm.nih.gov/pubmed/32385248 http://dx.doi.org/10.1038/s41467-020-16213-9 |